Zonulin and the intestinal barrier have a close relationship. Zonulin, also known as "zonula occludens toxin," is a protein present in the intestinal barrier. It is also referred to as a tight junction protein or adhesive protein. Its main function is to form tight connections between cells in the intestinal barrier, creating a seal and maintaining the integrity of the intestinal lining. It regulates the permeability between cells, balances the internal and external environment of the intestines, and prevents pathogens and other harmful substances from entering. This helps protect the intestines from damage and enhances the efficiency of nutrient absorption.
When there is an overgrowth of harmful bacteria in the intestines, Zonulin level increases, causing the intestinal barrier to become lax and resulting in leaky gut. This allows harmful bacteria and toxins to breach the barrier and enter the bloodstream, leading to inflammation and illness. It also impairs nutrient absorption, negatively affecting overall health. Therefore, maintaining healthy levels of Zonulin and inhibiting the proliferation of harmful bacteria are essential for preventing leaky gut syndrome and maintaining intestinal health.
The latest research from aXichem AB in Sweden demonstrates that Phenylcapsaicin, a phenolic compound, acts as a quorum sensing inhibitor, effectively inhibiting the aggregation and proliferation of harmful bacteria. It helps balance the gut microbiota, maintains normal levels of the tight junction protein Zonulin, reduces gut inflammation, and prevents intestinal permeability, promoting gut health.
*https://www.ncbi.nlm.nih.gov/pmc/?term=Phenylcapsaicin
*https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996528/
*https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372598/
Metabolox – Gut health and weight control capsule
Ingredient : Phenylcapsaicin (aXivite)
Dosage: Take one before a meal, 2 times daily
